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Most affiliated single-nucleotide polymorphisms determined in genome-vast association experiments of SLE are in non-coding areas, and thefunctional consequences For several are mysterious. DNA sequence variations can change DNA methylation states and gene expression, linking the regulatory genome with specific genetic hazard loci. Get an overview

Abnormal methylation of distinct genes relevant to heart failure, hypertension, and cardiovascular disease may be correlated to cardiovascular disease progression. DNA methylation may also be altered by repeated modulation from the microenvironment with the brain. In the case of recurrent seizures this microenvironment is frequently subject to unc